Acne Research Today is a free monthly online journal that collates and summarizes the latest research about Acne, including details on skin problems, diet, treatments, puberty.

Expanding the microcomedone theory and acne therapeutics: Propionibacterium acnes biofilm produces biological glue that holds corneocytes together to form plug.

Burkhart CG, Burkhart CN

University of Toledo School of Medicine, Sylvania, Ohio, USA.

The Propionibacterium acnes biofilm has previously been shown to exist via genomic studies and to make a biological glue which allows for adherence to follicular walls. This gylcocalyx polymer secreted by P acnes also finds its way into sebum composition where it causes the adhesiveness of keratinocytes leading to comedones. An appreciation of P acnes biofilms and secretions has implications in immunogenicity of the organism, clinical course of acne, and therapy for comedonal and inflammatory acne.

Published 17 September 2007 in J Am Acad Dermatol, 57(4): 722-4.
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