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Acne in recipients of renal transplantation treated with sirolimus: clinical, microbiologic, histologic, therapeutic, and pathogenic aspects.

Mahé E, Morelon E, Lechaton S, Drappier JC, de Prost Y, Kreis H, Bodemer C

Department of Dermatology, Bichat-Claude Bernard University Hospital, Paris, France. emmanuel.mahe@apr.aphp.fr

We evaluated the clinical characteristics of sirolimus-induced acne in 80 recipients of renal transplantation. It developed in 36 of 48 (75%) men and 2 of 32 (6%) women. Lesion locations and clinical, bacteriologic, and histologic features differentiated sirolimus-induced acne from acne vulgaris, but therapeutic management was similar. The main limitation for this study was the absence of a control group without sirolimus. Epidermal growth factor inhibition by sirolimus is a plausible explanation for this acne.

Published 19 June 2006 in J Am Acad Dermatol, 55(1): 139-42.
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