Acne Research Today is a free monthly online journal that collates and summarizes the latest research about Acne, including details on skin problems, diet, treatments, puberty.

Consequences of psychological distress in adolescents with acne.

Misery L

University of Brest, Laboratory of Skin Neurobiology, Brest, France. laurent.misery@chu-brest.fr

Acne may cause psychological distress that is associated with many psychiatric disorders. In this issue, Halvorsen et al. report suicidal ideation, mental health problems, and affective isolation to be relatively frequent in adolescents with acne. This report suggests that adverse events that have been attributed to therapies for acne, including suicidal ideation and depression, may reflect the burden of substantial acne rather than the effect of medications.

Published 13 January 2011 in J Invest Dermatol, 131(2): 290-2.
Full-text of this article is available online (may require subscription).

Articles on Acne published 13 January 2011:

Suicidal ideation, mental health problems, and social impairment are increased in adolescents with acne: a population-based study.   J Invest Dermatol, 131(2): 363-70.

We performed a cross-sectional, questionnaire-based study to explore the relationship of suicidal ideation, mental health problems, and social functioning to acne severity among adolescents aged 18-19 years. A total of 4,744 youth were invited and 3,775 (80%) participated. In all, 14% reported having substantial acne (a lot and very much). Among those with very much acne, as compared those with no/little acne, suicidal ideation was twice as frequently reported among girls (25.5 vs. 11.9%) and ... [Abstract] [Full-text]

Articles on Acne published 15 December 2010:

Propionibacterium acnes activates the IGF-1/IGF-1R system in the epidermis and induces keratinocyte proliferation.   J Invest Dermatol, 131(1): 59-66.

Propionibacterium acnes has a major role in the development of acne lesions. IGF-1 stimulates the proliferation of keratinocytes via an activation of the IGF-1 receptor (IGF-1R). Zinc has been proven to work efficiently against inflammatory acne and to modulate the IGF-1 system. Our objectives were to study the modulation of IGF-1 and IGF-1R expression by P. acnes extracts and to determine their modulation by zinc gluconate. In vivo, we analyzed biopsies of acne lesions and healthy skin, and in ... [Abstract] [Full-text]

Articles on Acne published 18 October 2010:

Underestimated clinical features of postadolescent acne.   J Am Acad Dermatol, 63(5): 782-8.

BACKGROUND: Postadolescent acne is usually described as an inflammatory, mild-to-moderate dermatosis, frequently involving the lower third of the face, the jawline, and the neck. However, we have also frequently observed a clinical form predominantly characterized by retention lesions (microcomedones and macrocomedones), with few inflammatory lesions (comedonal postadolescent acne [CPAA]), which appears significantly correlated with cigarette smoking. OBJECTIVE: We sought to investigate the ... [Abstract] [Full-text]

Articles on Acne published 15 September 2010:

Identification of a unique subset of 2-methylene-19-nor analogs of vitamin D with comedolytic activity in the rhino mouse.   J Invest Dermatol, 130(10): 2359-67.

The active metabolite of vitamin D, 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)), and a series of 2-methylene-19-nor analogs of 1,25(OH)(2)D(3) were evaluated for their ability to reduce the size of utricles (comedolytic activity) in a rhino mouse model of acne. All analogs tested, as well as the native hormone, increased the skin epidermal thickness. In contrast, only a subset of analogs that lacked a full side chain and 25-hydroxyl group were found to possess comedolytic activity. A reduction ... [Abstract] [Full-text]

Articles on Acne published 6 September 2010:

Isotretinoin use and the risk of inflammatory bowel disease: a case-control study.   Am J Gastroenterol, 105(9): 1986-93.

OBJECTIVES: Isotretinoin is commonly prescribed for the treatment of severe acne. Although cases of inflammatory bowel disease (IBD) have been reported in isotretinoin users, a causal association remains unproven. METHODS: We performed a case-control study using a large insurance claims database. Incident cases of IBD were identified and matched to three controls on the basis of age, gender, geographical region, health plan, and length of enrollment. Isotretinoin exposure was assessed in a ... [Abstract] [Full-text]

Articles on Acne published 29 July 2010:

Treatment of acne scars using subdermal minimal surgery technology.   Dermatol Surg, 36(8): 1281-7.

BACKGROUND: Acne is a common condition, seen in up to 80% of people aged 11 to 30. In some patients, it can result in permanent scars that are surprisingly difficult to treat, with current treatments for acne scars having limited efficacy. Recently, subdermal minimal surgery technology has been introduced as a novel therapeutic modality for acne scars. OBJECTIVE: To evaluate the clinical efficacy and safety of subdermal minimal surgery technology for treating acne scars. MATERIALS AND METHODS: ... [Abstract] [Full-text]

Articles on Acne published 16 July 2010:

Efficacy and safety of a carbon-dioxide ablative fractional resurfacing device for treatment of atrophic acne scars in Asians.   J Am Acad Dermatol, 63(2): 274-83.

BACKGROUND: Treatment of atrophic scars with a fractional laser resurfacing technique has demonstrated favorable outcomes, although data on the efficacy and adverse effects of this procedure in persons with dark-skinned phototypes are limited. OBJECTIVE: This study was conducted to evaluate the efficacy and safety of carbon-dioxide ablative fractional resurfacing on atrophic acne scars in Asian individuals. METHODS: Thirteen subjects (8 female and 5 male, aged 25-52 years) with skin phototype ... [Abstract] [Full-text]

Photodynamic therapy for acne vulgaris: a critical review from basics to clinical practice: part II. Understanding parameters for acne treatment with photodynamic therapy.   J Am Acad Dermatol, 63(2): 195-211; quiz 211-2.

Photodynamic therapy requires a photosensitizer, oxygen, and activating light. For acne, pilosebaceous units are "target" structures. Porphyrins are synthesized in vivo from 5-aminolevulinic acid (ALA), particularly in pilosebaceous units. Different photosensitizers and drug delivery methods have been reported for acne treatment. There are a variety of porphyrin precursors with different pharmacokinetic properties. Among them, ALA and methyl-ester of ALA (MAL) are available for ... [Abstract] [Full-text]

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